NFL Week 5 betting: Odds, lines and totals for every game

ByESPNESPN logo
Friday, October 9, 2026


Week 5 of the NFL season started with a big upset, as the heavily-favored Dallas Cowboysfell 24-16 to the visitingTampa Bay Buccaneers on "Thursday Night Football."

Ten of the remaining games have a spread of four points or lower. The Detroit Lions-Arizona CardinalsandBuffalo Bills-Los Angeles Ramsmatchups have the highest total of the week (54.5).

Here's a look at the odds for every game this week.

The Kansas City Chiefs and Carolina Panthers are on a bye. (You can find our early bets for Week 5 here.)

Jump to:

TB-DAL | JAX-PHI | CIN-MIA | NYG-WSH

CLE-NYJ | CHI-GB | LV-NE | IND-PIT

HOU-TEN | MIN-NO | DEN-LAC | SF-SEA

DET-ARI | BAL-ATL | BUF-LAR

Moneyline: Eagles (+300); Jaguars (-380)

Total: 41.5; Opened: 44.5

FPI favorite: Jaguars by 6.5 with a 73% probability to win the game outright

Moneyline: Bears (-120); Packers (+100)

Total: 45.5; Opened: 49.5

FPI favorite: Bears by 2.1 with a 58% probability to win the game outright

Check out the latest Super Bowl odds and major NFL awards futures.

Moneyline: Bengals (-325); Dolphins (+260)

Total: 42.5; Opened: 48.5

FPI favorite: Bengals by 9.1 with a 81% probability to win the game outright

Moneyline: Colts (+124); Steelers (-148)

Total: 44.5; Opened: 47.5

FPI favorite: Colts by 0.2 with a 51% probability to win the game outright

Moneyline: Giants (+160); Commanders (-192)

Total: 42.5; Opened: 48.5

FPI favorite: Commanders by 3.4 with a 63% probability to win the game outright

Moneyline: Browns (+114); Jets (-135)

Total: 39.5; Opened: 38.5

FPI favorite: Jets by 1.5 with a 56% probability to win the game outright

Moneyline: Raiders (+164); Patriots (-198)

Total: 45.5; Opened: 44.5

FPI favorite: Patriots by 3.6 with a 64% probability to win the game outright

Moneyline: Texans (-425); Titans (+330)

Total: 37.5; Opened: 43.5

FPI favorite: Texans by 4.3 with a 66% probability to win the game outright

Moneyline: Vikings (-142); Saints (+120)

Total: 41.5; Opened: 44.5

FPI favorite: Vikings by 0.8 with a 54% probability to win the game outright

Moneyline: Broncos (-180); Chargers (+150)

Total: 41.5; Opened: 44.5

FPI favorite: Chargers by 0.1 with a 51% probability to win the game outright

Moneyline: 49ers (+136); Seahawks (-162)

Total: 45.5; Opened: 46.5

FPI favorite: 49ers by 1.4 with a 56% probability to win the game outright

Moneyline: Lions (-258); Cardinals (+210)

Total: 54.5; Opened: 49.5

FPI favorite: Lions by 5.2 with a 69% probability to win the game outright

Moneyline: Ravens (+142); Falcons (-170)

Total: 43.5; Opened: 48.5

FPI favorite: Ravens by 2.4 with a 58% probability to win the game outright

Moneyline: Bills (+145); Rams (-175)

Total: 54.5; Opened: 53.5

FPI favorite: Rams by 2.4 with a 60% probability to win the game outright

Thursday's result

Final: Buccaneers 24, Cowboys 16

Moneyline: Buccaneers (+380); Cowboys (-500)

Total: 49.5; Opened: 52.5

FPI favorite: Cowboys by 11.2 with a 86.1% probability to win the game outright

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